How can you deliver a drug to kill tumors without killing the patient? How can you harness nanotechnology to design inexpensive kits to diagnose diseases in low-resource countries? How do you create functioning blood vessels to repair an injury or keep artificial organs alive? These are examples of “grand challenges” faced by practicing biomedical engineers that require us to design mathematical and experimental approaches for predicting, measuring, and interpreting flow phenomena quantitatively. In this course, you will combine your knowledge of applied mathematics and human physiology from the molecule to cell to whole body length scales to begin exploring how to answer grand challenge questions such as these.