BIMS8131-2/ PATH8130-40

TOPICS IN THE MOLECULAR BASIS HUMAN DISEASE

Course Objective: This two-semester course will address the biologic/molecular mechanisms related to selected disease processes.  The course is required for first year Medical Scientist Training Program (MSTP) and first year Pathology/Molecular Medicine graduate students.  The format consists of weekly meetings of 2 hours in duration and each topic will be covered in 2 sequential sessions with a combination of informal didactic presentations by the faculty and journal article discussions (3 pre-assigned papers maximum) by the students.  Didactic-style presentation(s) are aimed at providing sufficient background on the relevant pathobiology, histopathology, and/or clinical manifestations for the students to read and discuss the literature assignments.  A strong focus of the course will be the discussion of the basic pathobiologic processes and the contemporary biomedical translation of experimental science to the understanding and treatment of human diseases.  When possible, visits to clinical or research laboratories will allow observation of diagnostic procedures or translational research techniques.  All students are required to write an NIH-style mini-grant proposal based on one of the session topics.  In the final session, students will participate in a mock study section to review and score the applications. 

Enrollment:  Enrollment will be limited to a total of 16 students with preference given to full-time graduate students in the Pathology/Molecular Medicine Program, 1^st year students in the Medical Scientist Training Program, and medical students participating in graduate research programs.

Credit:  2 units

Grading: Pass/Fail

Course Director:  Jim Mandell, MD, PhD  (jwm2m)

Course Associate Directors:  Adam Goldfarb, MD (ang3x),

    Mani Mahadevan MD (msm8r)

Course Requirements:

1)           Attendance and participation in discussions for all sessions

2)           Satisfactory completion of mini-grant proposal (5 pages

maximum).  The objective of this exercise is to develop the student’s

ability to ask questions, identify an important problem, and write a

focused research proposal, in the style of an NIH grant application. 

Students may consult with course faculty during the preparation of

the mini-grant proposal.

3. Completion of course evaluation for each session and instructor

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TMBHD Fall 2014

Wednesdays 1:15-3:15 pm, MR6 3502 except 10/22: MR5 3005

(Module F1 for BIMS Program)

9/3 Osteoporosis Clinical Introduction -Alan Dalkin

9/10 Osteoporosis-Charles Farber

9/17 Multi-drug Resistant Tuberculosis-Clinical Introduction-Scott Heysell

9/24 Multi-drug Resistant Tuberculosis--Basic and Translational Approaches--Eric Houpt

10/1 No class (SOM Fall Break)

10/8 Grantsmanship 101 (Mandell, Mahadevan, Goldfarb)

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(Module F2 for BIMS Program)

10/15 Epilepsy-Clinical Introduction-Jaideep Kapur (or colleague)

10/22 Epilepsy-Basic and Translational Approaches--Jaideep Kapur

10/29 Breast Cancer-Clinical Introduction-Kristen Atkins

11/5 Breast Cancer-Basic and Translational Approaches-Kevin Janes

11/12 No class--work on Grant Proposals

11/19 Mock Study Section

This two-semester course will address the biologic/molecular mechanisms related to selected disease processes.  The course is required for first year Medical Scientist Training Program (MSTP) and first year Pathology/Molecular Medicine graduate students.  The format consists of weekly meetings of 2 hours in duration and each topic will be covered in 2 sequential sessions with a combination of informal didactic presentations by the faculty and journal article discussions (3 pre-assigned papers maximum) by the students.  Didactic-style presentation(s) are aimed at providing sufficient background on the relevant pathobiology, histopathology, and/or clinical manifestations for the students to read and discuss the literature assignments.  A strong focus of the course will be the discussion of the basic pathobiologic processes and the contemporary biomedical translation of experimental science to the understanding and treatment of human diseases.  When possible, visits to clinical or research laboratories will allow observation of diagnostic procedures or translational research techniques.  All students are required to write an NIH-style mini-grant proposal based on one of the session topics.  In the final session, students will participate in a mock study section to review and score the applications.