The course will cover the fundamentals in human genetics and genomics, including the basics of the human/mammalian genome, genome variation, determination of genomic variation on phenotype and disease risk, mapping and characterizing genetic variants on phenotype, determining the putative impact of genetic variants on gene expression (transcriptomics, epigenomics), the promise and implications of genome science on precision medicine and the ethical, legal and social impact of the personalized genomes. There will be development of skills using web-based tools, and use of simple R programs to interrogate data. A series of case studies in genome sciences will be presented. Selected web presentations are recommended.